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Three connected brain organoids reportedly learned to tell signals apart

BIOLOGY & NATURENEEDS REVIEWUpdated:

A report describes an experiment in which researchers connected one, two, or three human cerebral organoids—small clusters of neural tissue grown from reprogrammed human cells—on electrode-equipped chips. After the organoids had time to form connections, the networks received repeated electrical stimulation at two locations.

Three connected brain organoids reportedly learned to tell signals apart

Distinguishing signals through activity in the unstimulated third organoid

According to the report, software initially could identify the stimulated location from the resulting activity only about as often as guessing. After two weeks of repeated stimulation, that did not change for single organoids or pairs. In the three-organoid setup, however, activity in the third, unstimulated organoid reportedly became better at distinguishing which of the other two had received the signal.

The researchers interpret the result as a basic form of learning rather than anything like a complete brain's information processing. The striking mismatch is that adding a third connected tissue module, rather than simply repeating signals or growing the tissue longer, was reported to make the two signal sources distinguishable.

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