Something’s off.Two research teams reportedly traced orange cat fur to a missing 5-kilobase stretch of DNA near the Arhgap36 gene. The reported deletion is not in a protein-coding section, but is associated with much higher RNA expression from that gene in orange-fur skin cells.
The reported change sits on the X chromosome: males usually have one X chromosome, while females can form orange-and-dark patchworks when different skin-cell regions switch off different X chromosomes. Both teams reportedly identified Arhgap36.
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