Something’s off.A report describes an experiment in which 62 people received psilocybin and underwent brain scans while resting, meditating, listening to music, and watching clouds. Standard analyses still showed brain networks becoming less separate, a pattern often characterized as disorder.
But the researchers reportedly analyzed each person’s moment-by-moment activity rather than averaging it across time and participants. In that analysis, brain activity under psilocybin formed distinct paths for the four settings, and a classifier’s ability to identify the setting tracked with how profound participants said the experience was.
The reported mismatch is that brain activity can look broadly mixed when averaged, while retaining context-specific structure at shorter timescales. The researchers say this may help explain reports of a weaker boundary between self and the outside world, but the experiment involved healthy volunteers and does not establish how such findings would apply in treatment.
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