Creatine supplementation linked to improved hippocampal markers in rats with colitis
HealthUnverifiedUpdated:
Creatine supplementation reportedly improved several hippocampal markers in rats with induced colitis. This is preclinical animal evidence and does not establish brain-protective effects in humans.
Supplementation begins before induced colitis, with hippocampal measurements
Researchers gave some rats water containing creatine, then induced colitis 10 days later while continuing daily supplementation. ScienceAlert reports that, among rats with colitis, the supplement restored hippocampal creatine levels, reduced inflammation and neuronal damage, and improved markers of neuronal excitability. Reported benefits were more apparent in male rats than female rats.
The reported evidence is limited to rats and does not provide a comparable human treatment result.
In rats with experimentally induced colitis, daily creatine supplementation was reported to restore hippocampal creatine levels and improve several markers associated with neuronal health and activity.
The findings connect experimentally induced gut inflammation with changes in the hippocampus, a brain region involved in learning and memory, and identify creatine as a possible intervention in this animal model. The work remains preclinical, and its effectiveness in people is unclear.
Sources
- ScienceAlertCreatine Could Protect The Brain From Gut InflammationRead source →