Exercise and AdipoRon Linked to Preserved Ovarian Reserve in Mice
HealthUnverifiedUpdated:
A report on new mouse experiments links regular treadmill exercise to markers of preserved ovarian reserve, while AdipoRon-treated mice reproduced later in life; the human findings are observational associations, not proof of causation.
Follicles in exercise groups and reproductive lifespan with a drug
According to the report, female mice that ran regularly on a treadmill for one month had more ovarian follicles and lower primordial-follicle loss than mice that did not exercise.
Mice given AdipoRon, which stimulates adiponectin receptors, continued producing offspring to up to 15 months of age, compared with untreated mice that generally stopped around 12 months. The report also describes population-study associations involving physical activity, adiponectin-linked variants, and menopause timing.
The reported experiments compare exercised and untreated female mice, but do not establish that exercise prevents menopause in humans. No approved therapy to slow ovarian aging is identified in the report.
The study reportedly links treadmill exercise in mice with more ovarian follicles and less loss of primordial follicles, and finds that the experimental adiponectin-receptor drug AdipoRon extended reproductive lifespan in mice. It also reports associations between physical activity or adiponectin-linked genetic variants and later menopause in population data.
Human intervention benefits remain unestablished
The findings identify adiponectin, a protein hormone associated with ovarian follicle development and reserve, as a possible mediator of exercise-related effects in the mouse experiments. They point to targets for further research, but do not establish an exercise intervention or drug treatment for people.
Sources
- ScienceAlertOne Habit May Delay Ovarian Aging – And a Drug Could Mimic Its EffectsRead source →